Butabarbital will minimize the level or impact of amlodipine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check. butabarbital will reduce the level or influence of carvedilol by impacting hepatic enzyme CYP2C9/ten metabolism. Use Caution/Watch. butabarbital will lower the extent or effect of cannabidiol by influencing hepatic/intestinal enzyme CYP3A4 metabolis... https://frankv825tsq4.wikilinksnews.com/user