Under situations of reduced CB1R density, THC antagonises endogenous agonists possessing increased receptor efficacy than THC19. THC also allosterically modulates opioid receptors20, which can give more oblique routes for altering dopamine transmission21. Moreover, THC has psychoactive metabolites with CB1R affinity, even further complicating the analyses of receptor binding studies22... https://charlievdvch.dreamyblogs.com/33374190/a-simple-key-for-cannabis-strains-unveiled