If a mother or father of your proband is understood to possess the pathogenic variant recognized in the proband, the danger on the sibs of inheriting the pathogenic variant is 50%. On account of lowered penetrance, sibs who inherit the pathogenic variant might or might not acquire aHUS (see Penetrance). https://airhandlingunitahuhire11108.blogs100.com/32387081/air-handling-units-ahus-secrets